Current Issue Details

Current Issue Details Volume.2 ,Issue . 4

Manuscript Number
IJPRT-2023-11-059

Manuscript Title
Formulation of Natural Hair Oil by Propagation of Fenugreek Seed in Aloe Vera Leaf

Article Type
Original Research Articles

Author Names

Snehal Chakorkar *
Savita Shimple
Mandakini Holkar

Abstract
Hair plays a vital role in human life. Hair is an epidermal derivative, which is an essential part of increasing the body's overall elegance. Hair fall, dandruff, split ends, and grey hair are a few problems involved with hair faced by humans. To overcome these, human takes many measures by applying cosmetics for each. Hair oil is used to solve almost all of these problems. The present research has been undertaken to formulate and evaluate the pure herbal oil formulation by propagation of dried

Keywords .
Sprouted Fenugreek Seed in Aloe Vera gel, herbal Hair oil, anti-fungal

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Manuscript Number
IJPRT-2023-11-063

Manuscript Title
Formulation and Invitro Evaluation of Transdermal Patches of Nebivolol Hydrochloride

Article Type
Short Communication

Author Names

Mansi Pandit *
Dr. Sandip Kshirsagar
Dhanashree Punde

Abstract
Nebivolol is a highly cardio selective β1 -receptor blocker with nitric oxide -potentiating vasodilator effect and used in 50 mg dose for the treatment of the hypertension. Moreover, it is a long-acting antihypertensive agent preferred for treating chronic heart failure in high-risk patients. Transdermal drug delivery systems (TDDS) are adhesive drug-containing devices of defined surface area that deliver a predetermined amount of drug to the intact skin at a preprogrammed rate. The biopharmaceu

Keywords .
Nebivolol, Vasodilator, Biopharmaceutical classification, Transdermal patch, Transdermal drug delivery systems.

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Manuscript Number
IJPRT-2023-11-064

Manuscript Title
Development, Optimization and In Vitro Evaluation of Buccal Tablet of Posaconazole

Article Type
Original Research Articles

Author Names

Mrunal Satkar *
Dr. Rupali Dhamdhere
Dhanashree Punde

Abstract
Buccal route of administration has many advantages such as improving patient compliance, bypassing the GIT and hepatic first pass effect. The objectives are to formulate Mucoadhesive buccal tablet using Posaconazole and compatible excipients, and to evaluate the product using quality control tests and in vitro tests. In the development of buccal tablet of antifungal drug Posaconazole to treat oral thrush locally and to improve the solubility and bioavailability of drug, simultaneously enhances t

Keywords .
Posaconazole, Buccal, bioavailability, Mucoadhesive, ICH guidelines.

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Manuscript Number
IJPRT-2023-11-060

Manuscript Title
Efgartigimod: The Saviour for Autoimmune Condition

Article Type
Review Article

Author Names

Snehal Chakorkar *
Avanti Todkar
Divya Kakade
Shantanu Date

Abstract
Efgartigimod (efgartigimodalfa-fcab, Vyvgart™) is a first-in-class neonatal Fc receptor antagonist being developed by argenx for the treatment of autoimmune diseases including myasthenia gravis. It used specifically in generalized myasthenia gravis (gMG) in adults who are anti-acetylcholine receptor (AChR) antibody positive. Efgartigimod binds to the FcRn and inhibits its interaction with IgG, thereby reducing IgG recycling and increasing degradation of IgG and pathological auto antibodies, with

Keywords .
Efgartigimod, auto antibodies, Autoimmune, Immunoglobulins

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Manuscript Number
IJPRT-2023-11-062

Manuscript Title
Development and Evaluation of In - Situ Nasal Gel of Candesartan Cilexetil

Article Type
Original Research Articles

Author Names

Akash Hole *
Dr. Sandip Kshirsagar
Dhanashree Punde

Abstract
Now a day’s Nasal route is successfully used for the systemic delivery of various drugs like antidiabetic, antidepressants, vitamins and insulin delivery as it avoids first pass metabolism, gastrointestinal irritation, increases the bioavailability and residence time. The large surface area of the nasal mucosa offers a rapid onset of therapeutic effect, potential for direct-to-central nervous system delivery, no first-pass metabolism, and non- invasiveness; all of which may maximize patient conv

Keywords .
Gastrointestinal irritation, Bioavailability, first-pass metabolism, Mucoadhesive

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Manuscript Number
IJPRT-2023-11-061

Manuscript Title
Anticancer Medicinal Plants: A Review

Article Type
Review Article

Author Names

Tagare Janhavi *
Nigar Mujawar
Snehal Chakorkar

Abstract
Cancer is a condition in which abnormal cells multiply uncontrollably and can infiltrate surrounding tissues. The lymphatic and vascular systems of the body are further routes by which cancer cells might spread Research on cancer treatments has advanced significantly. Choices for cancer therapy range from the most traditional to the most cutting-edge. Surgery, chemotherapy, radiation therapy, and other techniques are used as therapies. The therapies used have some adverse effects on the normal c

Keywords .
Cancer; Medicinal Plants; Phytocompounds; Anticancer activity; Chemotherapy

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Manuscript Number
IJPRT-2023-11-066

Manuscript Title
Formulation and In-Vitro Evaluation of Gastroretensive Drug Delivery System of Ritonavir

Article Type
Original Research Articles

Author Names

Rushikesh Kolpe *
Dr. Rupali Dhamdhere
Dhanashree Punde

Abstract
The purpose of the research work was to develop a floating drug delivery system of Ritonavir in order to prolong the gastric residence time and increase its bioavailability. Gastroretensive retentive drug delivery system is designed with the aim to target the drug to its absorption site and to maintain the dosage form at that site for an extended period of time. To develop a floating Mucoadhesive tablet of ritonavir to prolong the gastric retention time for effective drug delivery system. Floati

Keywords .
Gastroretensive, Mucoadhesive, floating drug delivery system, effervescent.

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Manuscript Number
IJPRT-2023-11-067

Manuscript Title
Enhancement of Transdermal Permeability of drug by Formulation of Novel Dosage Form

Article Type
Original Research Articles

Author Names

Pradip Sonawane *
Dr. Rupali Dhamdhere
Dhanashree Punde

Abstract
Topical drug delivery systems significantly improve the therapeutic efficacy of drugs. Drug-release-retarding polymers are the key performers in such systems. The topical route of drug delivery is the most preferred route for administration of drugs. The rationale for the development of an emulgel formulation of a drug is to enhance its therapeutic benefits, minimizing its side effect while improving the management of the diseased condition. Psoriasis is an immune disease caused by rapid and inc

Keywords .
Emulgel, transdermal permeability, psoriasi

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Manuscript Number
IJPRT-2023-11-065

Manuscript Title
Development and in vitro Evaluation of Floating Mucoadhesive Tablet of Acebutolol Hydrochloride

Article Type
Original Research Articles

Author Names

Akshay Jagtap *
Dr. Sandip Kshirsagar
Dhanashree Punde

Abstract
In this study, it was intended to formulate floating Mucoadhesive tablets containing Acebutolol hydrochloride, an antihypertensive agent, to release the drug for a prolonged period of time in the upper part of the gastrointestinal tract in order to first-pass metabolism for improvement in bioavailability, to decrease the frequency of dosing, and to improve patient compliance. The effects of several polymers, including HPMC K4M and Carbopol 934, on the Mucoadhesive strength and release kinetics o

Keywords .
Mucoadhesive, Acebutolol hydrochloride, gastrointestinal, metabolism

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